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KMID : 0613820020120030349
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Journal of Life Science
2002 Volume.12 No. 3 p.349 ~ p.356
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The Effects of Panax Ginseng Extract on Antioxidative Enzyme Activity in Ovariectomized Rats
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Hwang Il-Young
Ha Bae-Jin
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Abstract
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In order to observe the bioactivity of ovariectomized rats, nonovariectoized (sham) group, ovariectomized (Ovx) group, ovariectomized ginseng total saponin (GTS)-treated (Ovx＋GTS) group and ovariectomized ginseng water extract (GW)-treated (Ovx＋GW) group were made. We measured AST (L-aspartate aminotransferase) and ALT (L-alanin aminotransferase) in sera, and MDA (malondialdehyde:lipid peroxidation), SOD (superoxide dismutase), catalase, total-glutathione (GSH＋GSSG) and GPx (glutathione peroxidase) in liver tissue total homogenates of rat. AST activity of serum in Ovx group was 2.11 times increased, but ALT activity was not changed compared to Sham group. In AST activity, they tend to decrease significantly in each substance such as GTS and GW administered group. Lipidperoxides of each fraction in Ovx group were highly increased compared to Sham group. Extracts of ginseng-treated group markedly inhibited lipid peroxidation by 62%～72%. And as the result of the measurements of SOD, catalase, total-glutathione and GPx which are antioxidant enzyme, antioxidant enzymes in Ovx group much lower than in Sham group. But they were significantly increased in each substance such as GTS and GW, administered group. Based on the results, it is supposed that more produced free radicals decreased antioxidant enzyme. And it is also thought that extracts of ginseng can inhibit aging by reducing antioxidant enzyme.
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KEYWORD
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Ginseng, saponin, aging, bioactivity, antioxidation
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